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KMID : 0357919870210030138
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Korean Journal of Pathology
1987 Volume.21 No. 3 p.138 ~ p.143
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Immunohistochemical Demonstration of Fibronectin in Paraquat-Induced Interstitial Fibrosis of Adult Human Lung
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Abstract
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We studied the distribution of fibronectin in paraquat-induced adult fibrotic lung by
indirect immunofluorescence and indirect immunoperoxidase methods, using
affinity-purified antifibronectin IgG peroxidase conjugates and antifibronectin IgG FITC
conjugates.
In contrast to the relative paucity of staining in normal lung, there was a marked
increase in interstitial staining for fibronectin in this fibrotic lung. This marked
alterations in the apparent amounts and distribution of fibronectin in fibrotic human lung
suggest its involvement in the cellular events accompanying human lung fibrosis.
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KEYWORD
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